2. Neurological Disease

Neurological Disease

Neurological Disease

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A range of neurological disorders, including epilepsy and dystonia, may involve dysfunctional intracortical inhibition, and may respond to treatments that modify it. Parkinson’s is a neurodegenerative disease characterized by increased activity of GABA in basal ganglia and the loss of dopamine in nigrostriatum, associated with rigidity, resting tremor, gait with accelerating steps, and fixed inexpressive face. Neurological deficits, along with neuromuscular involvement, are characteristic of mitochondrial disease, and these symptoms can have a dramatic impact on patient quality of life. Neurological features may be manifold, ranging from neural deafness, ataxia, peripheral neuropathy, migraine, seizures, stroke‐like episodes and dementia and depend on the part of the nervous system affected.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W001692
    Ocinaplon 96604-21-6 99.70%
    Ocinaplon (DOV 273547) is a partial GABAA receptor positive allosteric modulator with relatively high efficacy at the α1 subunit.
    Ocinaplon
  • HY-W004425
    DMPX 14114-46-6 98%
    DMPX (3,7-Dimethyl-1-propargylxanthine) is a BBB-penetrable caffeine analogue. DMPX is A2 selective adenosine receptor (AR) antagonist that strongly and selectively blocks hypothermia and behavioral inhibition induced by A2 adenosine receptor agonists such as NECA (HY-103173). DMPX can be used in the study of Parkinson's disease and other diseases.
    DMPX
  • HY-W005749
    (R)-4-Amino-3-hydroxybutyric acid 7013-07-2
    (R)-4-Amino-3-hydroxybutyric acid ((R)-GABOB) is a 4-aminobutyric acids (GABAB) agonist. (R)-4-Amino-3-hydroxybutyric acid is promising for research of nervous disorders.
    (R)-4-Amino-3-hydroxybutyric acid
  • HY-W008610
    GBR 12783 67469-57-2 98%
    GBR 12783 is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively. GBR 12783 can improve memory performance and increase hippocampal acetylcholine release in rats.
    GBR 12783
  • HY-W008645
    NCS-382 sodium 131733-92-1 ≥99.0%
    NCS-382 (sodium) is a potent GABA receptor antagonist. NCS-382 (sodium) has anti-sedative and anti-hypnotic activities and can be used in research related to neurological diseases.
    NCS-382 sodium
  • HY-W009267
    2-Amino-5-bromo-2′-fluorobenzophenone 1479-58-9 98%
    2-Amino-5-bromo-2′-fluorobenzophenone is a precursor in the synthesis of Flubromazepam.
    2-Amino-5-bromo-2′-fluorobenzophenone
  • HY-W009754
    Antidepressant agent 10 87691-87-0 99.96%
    Antidepressant agent 10 (Compound 4) is an orally active compound. Antidepressant agent 10 has IC50 values of 190 nM and 110 nM for 5-HT1A and 5-HT2, respectively. Antidepressant agent 10 can be used in the research of mental disorders.
    Antidepressant agent 10
  • HY-W010130
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone 22246-18-0 99.96%
    7-Hydroxy- 3, 4- dihydro- 2(1H) - quinolinone (3,4-Dihydro-7-hydroxy-2(1H)-quinolinone) is a weak MAO-A inhibitor, with an IC50 of 183 μM, and has no effect on MAO-B.
    7-Hydroxy-3,4-dihydro-2(1H)-quinolinone
  • HY-W016591
    2,4-Diisopropylphenol 2934-05-6
    2,4-Diisopropylphenol is a widely accepted chemical agent.
    2,4-Diisopropylphenol
  • HY-W017500
    N-Methyl-DL-aspartic acid 17833-53-3 ≥98.0%
    N-Methyl-DL-aspartic acid is a glutamate analogue and a NMDA receptor agonist and can be used for neurological diseases research.
    N-Methyl-DL-aspartic acid
  • HY-W056439
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine 224779-27-5 98%
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine can increase the activity of β-glucocerebrosidase by 20%. N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine can be used in the study of lysosomal storage diseases and other protein storage diseases.
    N-Boc-3-hydroxy-1,2,3,6-tetrahydropyridine
  • HY-W070306
    PDK1-IN-1 1207836-10-9
    PDK1-IN-1 (Compound 2-11) is a PDK1 inhibitor, and can be used for research of myeloproliferative disorders or cancer.
    PDK1-IN-1
  • HY-W077477
    IHCH-7113 313368-85-3 98%
    IHCH-7113 (Compound 166) is an agonist of 5-HT2A serotonin receptor with antidepressant activity. IHCH-7113 is promising for research of antipsychotic agent.
    IHCH-7113
  • HY-W089856
    Chlorobutanol hemihydrate 6001-64-5 ≥98.0%
    Chlorobutanol hemihydrate is an antimicrobial agent with oral activity, also possessing preservative effects. Chlorobutanol hemihydrate exhibits resistance to a variety of Gram-positive and Gram-negative bacteria, as well as several fungal spores and fungi, and is widely used in the food and cosmetics industries.
    Chlorobutanol hemihydrate
  • HY-W089922
    D-erythro-Sphingosine hydrochloride 2673-72-5
    D-erythro-Sphingosine (Erythrosphingosine) hydrochloride is a specific TRPM3 activator. D-erythro-Sphingosine also induces retinoblastoma protein dephosphorylation.
    D-erythro-Sphingosine hydrochloride
  • HY-W090292
    Olivetolic acid 491-72-5 99.82%
    Olivetolic acid is a biosynthetic precursor of cannabinol acid (CBGA). Olivetolic acid has anticonvulsant activity.
    Olivetolic acid
  • HY-W098756
    Thionordiazepam 4547-02-8 98%
    Thionordiazepam is a benzodiazepine compound and serves as an analytical reference standard for benzodiazepine-related psychoactive substances.
    Thionordiazepam
  • HY-W100209
    5Me3F4AP 13958-85-5 99.55%
    5Me3F4AP is a potent blocker of potassium channel, with the IC50 of 220 μM to 693 μM when the pH is increased from 6.4 to 9.1. 5Me3F4AP has the potential to cross the blood-brain barrier and potential application in positron emission tomography (PET).
    5Me3F4AP
  • HY-W100249
    MMAI 136468-19-4 99.08%
    MMAI is a selective serotonin releaser that can be used in the research of mental illnesses.
    MMAI
  • HY-W129359
    11β-HSD1-IN-8 386704-15-0
    11β-HSD1-IN-8 (compound c6a) is a 11β HSD1 inhibitor with an IC50 value of 2.3 μM for human 11β HSD1. 11β-HSD1-IN-8 can be used for the research of diabetes and cognitive decline.
    11β-HSD1-IN-8
Cat. No. Product Name / Synonyms Application Reactivity